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Beyond's Guide to Prenatal Supplements

August 6, 2026
5 min read

1. The Foundation of a Quality Prenatal

Not all prenatal vitamins are created equal. When reviewing a Supplement Facts label, we recommend looking for nutrient amounts that are as close as possible to the following evidence-based targets.

Nutrient Recommendations & Context
Folate / Folic Acid 400–800 mcg. If you have concerns about folic acid metabolism, you can add a methylated folate rather than ordering routine MTHFR genetic testing. If you have an MTHFR variant: Continue taking 400 mcg of folic acid and, if desired, you may add 400 mcg of methylfolate after discussing it with your healthcare provider. (See note below.)
Iron Approximately 27 mg (unless you have a specific medical condition where supplemental iron should be avoided). This is critically important for expanding maternal blood volume and supporting fetal development.
Iodine 150 mcg to structurally support healthy fetal brain development and maternal/fetal thyroid function.
Vitamin D At least 600 IU; however, we may choose to individualize this dosing based directly on your serum blood levels.
Vitamin B12 Aim for at least 2.6 mcg daily during pregnancy (most prenatal vitamins contain 4–12 mcg, which is appropriate). Vitamin B12 is especially important for individuals following a vegetarian or vegan diet and for those taking additional methylfolate, as adequate B12 helps support healthy folate metabolism, red blood cell production, and fetal nervous system development.
Choline Ideally 450 mg during pregnancy. Most standard prenatals do not contain enough due to space restrictions, meaning many people require an additional choline supplement or targeted dietary sources (especially eggs).
DHA (Omega-3) Approximately 200–300 mg if you are not routinely consuming adequate amounts of low-mercury fish.

A Note on Folate

Folic acid is the form of folate that has been extensively studied and proven to reduce the risk of neural tube defects during pregnancy. For this reason, we recommend choosing a prenatal vitamin that contains at least 400 mcg of folic acid.

If you have a known MTHFR variant or are concerned about folate metabolism, it is reasonable to add an additional 400 mcg of methylfolate (5-MTHF) to a prenatal vitamin that already contains 400 mcg of folic acid. However, based on current evidence, methylfolate should not replace folic acid during preconception or pregnancy, as it has not been studied as extensively for neural tube defect prevention.

2. Making the Most of Your Prenatal

Keep these foundational principles in mind as you begin selecting your prenatal vitamin:

  • Timeline Strategy: Start your prenatal vitamin at least 3 months before trying to conceive. This gives your body time to build up key nutrient stores that support healthy egg development, early fetal growth, and a healthy pregnancy from the very beginning.
  • Whole-Food First: Prenatal vitamins are meant to supplement a healthy diet—not replace one. Think of them as a nutritional safety net, helping fill in potential gaps while supporting a healthy pregnancy.
  • The Gummy Limitation: Gummy prenatal vitamins can be a convenient option, but they often do not contain iron (which may or may not be needed depending on your individual needs) and may also be missing other important nutrients, such as iodine. If you choose a gummy prenatal vitamin, carefully review the Supplement Facts label to ensure it provides the key nutrients recommended during preconception and pregnancy.
  • Managing Constipation: If your prenatal vitamin causes constipation, don't stop taking it without first discussing alternatives with your Beyond Care provider. Instead, we recommend managing constipation proactively by staying well hydrated, increasing your dietary fiber intake, remaining physically active, and using a stool softener if needed. If symptoms persist, switching to a prenatal vitamin that contains a gentler form of iron, such as iron bisglycinate, may help improve tolerability.

3. Brand Comparison Chart

The following chart allows you to cross-compare major brands against standard fertility targets:

Brand Folate Form / mcg Iron (27mg) Iodine (150mcg) Vitamin D Choline DHA
Needed (Capsules) Methylated / 800 mcg 0 mg (Separate) 250 mcg 4,000 IU 400 mg 0 mg (Separate)
Ritual Methylated / 1000 mcg DFE 18 mg (Gentle) 150 mcg 2,000 IU 55 mg (Low) 350 mg (Vegan)
FullWell Methylated / 800 mcg 0 mg (Separate) 250 mcg 4,000 IU 300 mg 0 mg (Separate)
Thorne Methylated / 1,700 mcg DFE 45 mg 150 mcg 1,000 IU 0 mg 0 mg (Separate)
Nature Made (Softgel) Folic Acid / 1,330 mcg DFE 27 mg 150 mcg 1,000 IU 0 mg 200 mg
One A Day (Softgel Combo) Folic Acid / 800 mcg 28 mg 150 mcg 800 IU 0 mg 200 mg
SmartyPants (Gummy) Methylated / 1,200 mcg DFE 0 mg 150 mcg 1,200 IU 18 mg (Low) 114 mg
Luminary (Gummy) Methylated / 800 mcg 15 mg (Low) 150 mcg 2,000 IU 50 mg (Low) 300 mg

Green: meets target · Yellow: partially present / low · Red: missing / requires separate supplement

A Note from Our Team

Our goal is to provide you with evidence-based information so you can make informed decisions about your health. Every person and every fertility journey is unique, and the "best" prenatal vitamin depends on your individual health history, laboratory results, diet, and specific nutritional needs.

This guide is intended for educational purposes only and should not replace personalized medical advice. Please discuss any questions about supplements or prenatal vitamins with your Beyond provider or OBGYN before making changes to your routine.

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